Inhibiting TLR7, an immune signaling protein, may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer's disease and ordinary aging, suggests a study led by researchers at Weill Cornell Medicine. The research is published in the journal Science....
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Published on: 12-04-24
Researchers at Columbia University Mailman School of Public Health have developed a novel computational pipeline designed to identify protein biomarkers associated with complex diseases, including Alzheimer's disease (AD). This innovative tool analyzes biomarkers that can induce 3D structural changes in proteins, providing critical insights into disease mechanisms and highlighting potential...
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Published on: 12-04-24
Researchers from Saint Michael's College and the University of Vermont have made a new discovery that provides a better understanding of how Alzheimer's disease develops in the human brain....
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Published on: 12-03-24
Patients with frontotemporal dementia often lack the ability to empathize. A study has now shown that these patients do not show the same brain activity as healthy individuals when they witness the pain of others, a finding that it is hoped will increase understanding of this specific dementia disease....
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Published on: 12-03-24
Patients with frontotemporal dementia often lack the ability to empathize. A study at Karolinska Institutet has now shown that these patients do not show the same brain activity as healthy individuals when they witness the pain of others, a finding that it is hoped will increase understanding of this specific...
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Published on: 12-03-24
Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide. Familial Alzheimer's disease (FAD), a rare inherited form of the disease, is linked to mutations in several genes, including APP, PSEN1, and PSEN2. The impact of PSEN2 mutations has...
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Published on: 12-03-24
The risk of developing dementia later in life is strongly predicted by a person's cognitive ability, functional limitations and physical health as many as 20 years before onset of the illness, according to a new RAND report....
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Published on: 12-03-24
Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study. The researchers emphasized that lifestyle modifications targeted at reducing this fat could...
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Published on: 12-02-24
Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease....
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Published on: 12-02-24
Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a study being presented at the annual meeting of the Radiological Society of North America...
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Published on: 12-02-24
After strange doings next door, an elderly neighbor vanishes — then reappears angry and confused on their doorstep....
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Published on: 11-29-24
The U.K.'s leading hearing loss organizations have joined forces to highlight misleading reports by some health professionals and the media that hearing loss causes dementia, and treating hearing loss will reduce our individual risk of dementia....
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Published on: 11-29-24
When Dad first started forgetting things, I thought I’d lost him. I didn’t imagine I’d have more of him than I did before....
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Published on: 11-29-24
Alzheimer's disease is one of the world's biggest health problems. Yet, despite the fact millions of people globally are diagnosed with the disease each year, it remains a challenge to treat. This is largely because the underlying causes are still not fully understood....
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Published on: 11-28-24
A decade ago, researchers introduced a new model for studying Alzheimer's disease. Known as "Alzheimer's in a dish," the model uses cultures of mature brain cells suspended in a gel to recapitulate what takes place in the human brain over 10 to 13 years in just six weeks....
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Published on: 11-27-24
A new study from the University of Liverpool represents a significant step forward in scientists' understanding of Alzheimer's disease. Researchers have shed new light on how mechanical signaling in the brain is disrupted and could lead to the condition, which accounts for 60%–80% of dementia cases worldwide....
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Published on: 11-27-24
Thanksgiving travel is a must for millions of Americans, but those plans will be complicated for some because they're traveling with a loved one who has Alzheimer's disease or dementia....
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Published on: 11-27-24
Subtle signs of Alzheimer's disease can emerge decades before a diagnosis—often in the form of irregular behaviors that reflect very early stages of brain dysfunction. But until now, identifying and measuring these slight behavioral changes in a scientific way hasn't been feasible, not even when studying Alzheimer's in mice....
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Published on: 11-26-24
Imagine gradually losing the ability to express yourself—not because you've forgotten the words, but because they simply won't come out. This is the reality for individuals living with primary progressive aphasia (PPA), a rare form of dementia that usually begins in middle age and increasingly impairs language abilities over time....
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Published on: 11-26-24
The first drugs against Alzheimer's disease that are intended to slow down the progression of the condition will soon be authorized in Germany. On November 14, 2024, the EMA granted approval for Lecanemab in the European Union. The drugs attack so-called amyloid plaques in the brain....
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Published on: 11-25-24
As Baby Boomers hit retirement, about 1 in 6 Americans is now over the age of 65. The number of Americans living with dementia is projected to skyrocket—but the proportion of older Americans who develop dementia has actually decreased. The exact reason why is uncertain, but various lifestyle and environmental...
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Published on: 11-25-24
A brain region affected very early in Alzheimer's disease may explain why some aging people are at greater risk of financial exploitation. That is the key finding of our new study, published in the journal Cerebral Cortex....
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Published on: 11-25-24
A loss of brain volume associated with new immunotherapies for Alzheimer's disease may be caused by the removal of amyloid plaques, rather than the loss of neurons or brain tissue, finds a study led by UCL researchers....
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Published on: 11-25-24
A new neuroimaging marker of cerebral small vessel disease is related to general cognition and may serve to identify persons at risk of dementia in future clinical trials, a landmark study has found....
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Published on: 11-21-24
Centiloid guidelines and recommendations released for clinical context-of-use in Alzheimer's disease
The members of the Amyloid imaging to prevent Alzheimer's disease (AMYPAD) have announced the publication of a perspective review on the interpretability and clinical application of the Centiloid (CL) scale, a robust method for measuring amyloid plaques in the brain, a key hallmark of Alzheimer's disease (AD)....
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Published on: 11-21-24
They show up as bright white spots when you get a brain MRI: lesions called white matter hyperintensities, or WMH. And their presence suggests something may be wrong with your brain's white matter—there could be structural abnormalities....
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Published on: 11-21-24
An estimated 13.8 million people in the U.S. will have Alzheimer's disease (AD) by 2050, two thirds of whom are projected to be women. The brain circuitry underlying memory is widely known to differ based on biological sex, but sex-based drivers of aging and AD are still unclear....
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Published on: 11-21-24
Historical policies shaping educational attainment have enduring benefits for later life memory and risk of dementia, according to a new study. The study compared the differences in years of education based on variations in state schooling mandates with cognitive performance outcomes in residents decades later....
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Published on: 11-20-24
Historical policies shaping educational attainment have enduring benefits for later life memory and risk of dementia, according to a study led by a Rutgers Health researcher....
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Published on: 11-20-24
Dementia disproportionately affects women whether living with dementia or supporting someone living with dementia in aged care, a fact largely ignored in the final report of the Aged Care Royal Commission, an analysis by QUT health law researchers has found....
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Published on: 11-20-24
A new study by researchers from Regenstrief Institute, Indiana University and Purdue University presents their low cost, scalable methodology for the early identification of individuals at risk of developing dementia. While the condition remains incurable, there are a number of common risk factors that, if targeted and addressed, can potentially...
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Published on: 11-20-24
A study by researchers presents their low cost, scalable methodology for the early identification of individuals at risk of developing dementia. While the condition remains incurable, there are a number of common risk factors that, if targeted and addressed, can potentially reduce the odds of developing dementia or slow the...
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Published on: 11-20-24
High cardiorespiratory fitness is associated with better cognitive performance and lower risk of dementia in the long term, including in people with a genetic predisposition to dementia, show the findings of a study published online in the British Journal of Sports Medicine....
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Published on: 11-19-24
Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study....
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Published on: 11-19-24
Alzheimer's disease affects more than 50 million people worldwide, often devastating both the individuals who have it and their families and loved ones. It has no known cure, and the slow, progressive nature of the disease makes early diagnosis difficult....
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Published on: 11-19-24
In a recent study, Tel Aviv Sourasky Medical Center has shed light on physician attitudes toward novel anti-amyloid treatments (ATT) for Alzheimer's disease (AD), revealing a spectrum of opinions across key specialties. With Israel's health system structured to provide universal health care, the high out-of-pocket costs for new AD therapies...
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Published on: 11-19-24
People diagnosed with type 2 diabetes at a younger age are at a higher risk for developing dementia than those diagnosed later in life, according to a new study. The findings show that the increased risk is especially pronounced among adults with obesity....
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Published on: 11-19-24
A recently published study found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders....
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Published on: 11-19-24
People diagnosed with type 2 diabetes at a younger age are at a higher risk for developing dementia than those diagnosed later in life, according to a study led by researchers at the NYU Rory Meyers College of Nursing. The findings, published in PLOS ONE, show that the increased risk...
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Published on: 11-19-24
Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study from Karolinska Institute, published in Alzheimer's & Dementia....
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Published on: 11-19-24
Dementia-friendly travel options such as cruises and guided tours are needed to support a growing population of families and caregivers dealing with dementia....
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Published on: 11-19-24
A quick finger prick and a few drops of blood on a card that can be sent in regular mail—This approach could soon make Alzheimer's testing much more accessible worldwide. A European study led by researchers at the University of Gothenburg, Sweden, is paving the way for this method....
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Published on: 11-18-24
The way people living with dementia experience the world can change as the disease progresses. Their sense of reality or place in time can become distorted, which can cause agitation and distress....
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Published on: 11-18-24
A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient....
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Published on: 11-14-24
Researchers led by the University of California, Irvine are the first to reveal how two neural circuits located in the brain's retrosplenial cortex are directly linked to spatial navigation and memory storage. This discovery could lead to more precise medical treatments for Alzheimer's disease and other cognitive disorders by allowing...
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Published on: 11-14-24
Europe's medicines watchdog on Thursday partially approved a marketing request for a long-awaited new treatment for Alzheimer's disease, reversing an earlier decision not to give it the green light....
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Published on: 11-14-24
Mitochondria play an essential role in maintaining cellular health. When damaged, they are removed through a recycling process called mitophagy, which is crucial for the function of long-lived cells, especially in the brain. Impaired mitophagy has been strongly associated with neurodegenerative disorders like Alzheimer's and Parkinson's disease, making it a...
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Published on: 11-14-24
Structural analysis shows Alzheimer's disease mutation produces 'cottonwool' structures in the brain
An international collaboration led by RIKEN researchers has discovered how unusual spherical structures form in the brains of people with a mutation that causes a form of inherited Alzheimer's disease. This discovery could help better understand the mechanics of the debilitating neurodegenerative disease....
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Published on: 11-14-24
Age-adjusted dementia deaths rates were stable between 2018 and 2019, then increased in 2020 and decreased slightly in 2022, according to a report published in the November Health E-Stats....
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Published on: 11-14-24
Researchers are calling people of Hispanic descent to help find and trace plaques linked to dementia. Their work, supported by an NIH grant, helps speed up research on Alzheimer’s....
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Published on: 11-14-24